Mesodermal cell fate specification

Across TCGA patient cohorts, RNA activity of the Mesodermal cell fate specification pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SART1, HAGHL, and AXIN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesodermal cell fate specification activity versus SART1 in UCEC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SART1 →	+0.799	+0.365	<.001	.005	3	4
CCRCC	HAGHL →	+0.801	+0.187	.002	.001	3	3
UCEC	AXIN1 →	+0.674	+0.351	<.001	.007	3	3
UCEC	PARD3 →	+0.608	+0.327	.001	.005	3	3
UCEC	NBL1 →	+0.770	+0.240	.003	.001	3	3
LSCC	KLC2 →	+0.485	+0.694	.003	.005	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007501 vs SART1 — UCEC

Explore this scatter interactively →