Mesodermal cell fate specification

Across TCGA cell cohorts, RNA activity of the Mesodermal cell fate specification pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXorf38, SERPINB8, and ITCH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CXorf38 grouped by Mesodermal cell fate specification-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CXorf38 →	+0.839	+1.135	.001	.001	3	5
LUNG_NSCLC_LUSC	SERPINB8 →	-1.124	-1.607	.009	<.001	3	5
STOMACH	ITCH →	+0.769	+1.248	.004	<.001	2	5
URINARY_TRACT	PPP1R3E →	-2.030	-2.239	.001	<.001	3	4
BLOOD_Myeloma	DPM1 →	+1.018	+1.014	.001	.008	3	4
CNS	C14orf93 →	-0.496	-0.807	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CXorf38 by Mesodermal cell fate specification activity — BLOOD_Leukemia

Explore this box plot interactively →