Salivary gland development

Across TCGA cell cohorts, RNA activity of the Salivary gland development pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IQCN, XYLT1, and APOL6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IQCN grouped by Salivary gland development-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	IQCN →	+0.862	+1.407	<.001	<.001	3	4
STOMACH	XYLT1 →	-1.295	-0.861	.001	.005	3	4
CNS	APOL6 →	+0.822	+0.827	.009	.001	3	4
LARGE_INTESTINE	TCEANC2 →	+0.556	+1.103	<.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	NCOA3 →	+0.962	+0.906	.003	.007	2	4
UPPER_AERODIGESTIVE_TRACT	TMC1 →	+0.329	+1.111	<.001	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IQCN by Salivary gland development activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →