Peripheral nervous system development

Across TCGA patient cohorts, RNA activity of the Peripheral nervous system development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GSTM3, PI4KA, and PAPOLA_S545, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peripheral nervous system development activity versus GSTM3 in BRCA (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GSTM3 →	+0.805	+0.022	<.001	.002	3	7
COAD	PI4KA →	+0.200	+0.027	<.001	<.001	3	6
GBM	PAPOLA_S545 →	-0.523	-0.071	<.001	<.001	3	6
LSCC	SRRM1_T727 →	-0.484	-0.049	.001	.001	3	5
GBM	ALDH1A1 →	+0.537	+0.063	.005	.001	3	5
GBM	MAPRE3 →	+0.403	+0.058	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007422 vs GSTM3 — BRCA

Explore this scatter interactively →