Synapse assembly

Across TCGA patient cohorts, RNA activity of the Synapse assembly pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN2, LRRC4C, and IGFBP7, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synapse assembly activity versus TSPAN2 in OV (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TSPAN2 →	+1.234	+1.069	<.001	.001	3	2
OV	LRRC4C →	+0.782	+0.977	.002	.002	3	2
OV	IGFBP7 →	+1.041	+1.061	.002	.001	3	2
OV	IGFBP7-AS1 →	+0.202	+0.994	.006	<.001	3	2
BRCA	CDO1 →	+1.397	+0.510	.008	.006	3	2
COAD	SFRP1 →	+1.033	+0.717	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007416 vs TSPAN2 — OV

Explore this scatter interactively →