Axon guidance

Across TCGA cell cohorts, RNA activity of the Axon guidance pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN1A, ESYT2, and LRPAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDKN1A grouped by Axon guidance-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CDKN1A →	-1.981	-0.927	.007	<.001	3	5
STOMACH	ESYT2 →	-1.113	-0.225	.002	.002	3	4
CNS	LRPAP1 →	-0.620	-0.587	.006	.001	3	4
UPPER_AERODIGESTIVE_TRACT	CIB1 →	-1.179	-0.170	.004	<.001	3	4
SKIN	SESN1 →	-1.079	-1.117	.001	<.001	3	3
LUNG_SCLC	ZNF706 →	-1.030	-0.184	.001	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDKN1A by Axon guidance activity — SKIN

Explore this box plot interactively →