Neuroblast proliferation

Across TCGA patient cohorts, RNA activity of the Neuroblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHD8, EP300, and USP34, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuroblast proliferation activity versus CHD8 in DLBC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	CHD8 →	+0.849	+0.036	<.001	<.001	3	33
DLBC	EP300 →	+1.473	+0.036	<.001	<.001	3	32
DLBC	USP34 →	+1.652	+0.038	<.001	<.001	3	32
DLBC	EMSY →	+0.879	+0.039	<.001	<.001	3	32
DLBC	TAOK1 →	+1.045	+0.047	<.001	.001	3	32
DLBC	NCOA6 →	+0.926	+0.036	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007405 vs CHD8 — DLBC

Explore this scatter interactively →