Neuroblast proliferation

Across TCGA patient cohorts, RNA activity of the Neuroblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IMPA2, CSMD2, and CECR7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuroblast proliferation activity versus IMPA2 in PDAC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	IMPA2 →	-0.484	-0.426	<.001	<.001	3	4
PDAC	CSMD2 →	+0.398	+0.407	<.001	.001	3	4
BRCA	CECR7 →	+1.239	+0.335	<.001	.006	3	4
PDAC	STON1 →	+0.569	+0.558	<.001	<.001	3	4
CCRCC	ZC2HC1C →	-0.210	-0.497	.005	.007	3	3
BRCA	TBC1D30 →	-0.574	-0.323	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007405 vs IMPA2 — PDAC

Explore this scatter interactively →