Ectoderm development

Across TCGA patient cohorts, RNA activity of the Ectoderm development pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MMGT1, RPL10A, and SEPTIN4_S432, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ectoderm development activity versus MMGT1 in PDAC (Pearson r = -0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MMGT1 →	-0.641	-0.036	<.001	.003	3	7
OV	RPL10A →	-0.302	-0.055	.002	.002	3	7
GBM	SEPTIN4_S432 →	+0.639	+0.058	<.001	<.001	3	7
CCRCC	TNS2_S120 →	+0.498	+0.060	<.001	<.001	2	8
COAD	VCL_S795 →	+0.533	+0.050	<.001	<.001	3	7
PDAC	AHNAK_S5448 →	+0.735	+0.059	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007398 vs MMGT1 — PDAC

Explore this scatter interactively →