Ectoderm development

Across TCGA patient cohorts, RNA activity of the Ectoderm development pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GVQW3, HLA-DPA3, and RNU6-344P, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ectoderm development activity versus GVQW3 in HNSC (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GVQW3 →	-0.520	-0.119	.001	.005	3	5
GBM	HLA-DPA3 →	-0.566	-0.150	.003	.006	3	4
GBM	RNU6-344P →	-0.601	-0.223	.008	<.001	3	4
COAD	IL1RN →	+1.610	+0.162	<.001	<.001	3	4
LSCC	PI3 →	+1.739	+0.115	<.001	<.001	3	4
LSCC	DUSP7 →	+0.614	+0.142	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007398 vs GVQW3 — HNSC

Explore this scatter interactively →