Ectoderm development

Across TCGA patient cohorts, RNA activity of the Ectoderm development pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRRM1_S560, MDC1_S495, and S100A8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ectoderm development activity versus SRRM1_S560 in PDAC (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SRRM1_S560 →	-0.697	-0.184	<.001	<.001	3	4
OV	MDC1_S495 →	-1.325	-0.294	<.001	<.001	3	4
COAD	S100A8 →	+1.410	+0.138	<.001	.001	3	4
COAD	S100A9 →	+1.144	+0.125	<.001	<.001	3	4
LSCC	DSP_S53 →	+0.848	+0.146	.001	<.001	3	4
OV	RIPK3_S410 →	-0.944	-0.185	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007398 vs SRRM1_S560 — PDAC

Explore this scatter interactively →