Ectoderm development

Across TCGA cell cohorts, RNA activity of the Ectoderm development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDS1, BEST1, and BEST4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDS1 grouped by Ectoderm development-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CDS1 →	+2.574	+1.592	<.001	<.001	3	4
LUNG_NSCLC_LUAD	BEST1 →	-0.638	-0.927	.001	<.001	3	4
BLOOD_Leukemia	BEST4 →	-0.110	-1.125	.005	.003	3	4
BLOOD_Leukemia	EDC3 →	+0.696	+1.004	.006	.008	3	4
SKIN	RPP14 →	-0.396	-0.850	.001	.003	3	4
SOFT_TISSUE	ZNF649 →	-1.368	-1.306	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDS1 by Ectoderm development activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →