Ectoderm development

Across TCGA cell cohorts, RNA activity of the Ectoderm development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA6, DSE, and MFAP3L, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ectoderm development activity versus ITGA6 in SOFT_TISSUE (Pearson r = 0.95).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ITGA6 →	+4.680	+2.226	.001	.002	2	7
SKIN	DSE →	+3.433	+2.137	.005	.002	3	5
SKIN	MFAP3L →	-1.896	-1.456	.003	.008	3	4
BREAST	CACFD1 →	-1.691	-2.078	.002	<.001	3	4
LUNG_NSCLC_LUSC	SMAD9 →	-2.313	-2.154	.004	<.001	3	4
SKIN	G3BP2 →	-1.169	-1.997	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007398 vs ITGA6 — SOFT_TISSUE

Explore this scatter interactively →