Gastrulation

Across TCGA patient cohorts, RNA activity of the Gastrulation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ISM1, SNPH, and SFXN3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gastrulation activity versus ISM1 in OV (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ISM1 →	+1.859	+0.211	<.001	<.001	3	3
COAD	SNPH →	+0.619	+0.103	.009	.009	3	3
BRCA	SFXN3 →	+0.986	+0.173	.002	.006	3	3
OV	SH3PXD2A →	+1.635	+0.176	.004	.002	3	3
COAD	PCDH12 →	+0.868	+0.221	<.001	<.001	3	3
OV	FGF1 →	+2.368	+0.248	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007369 vs ISM1 — OV

Explore this scatter interactively →