Gastrulation

Across TCGA cell cohorts, RNA activity of the Gastrulation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT18, TP53I11, and RREB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KRT18 grouped by Gastrulation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KRT18 →	-3.227	-0.167	.004	.001	3	5
BREAST	TP53I11 →	-1.600	-0.186	.004	<.001	3	5
BLOOD_Lymphoma	RREB1 →	-1.064	-0.303	.001	.003	3	4
BLOOD_Leukemia	EML6 →	+1.447	+0.194	.003	.003	2	5
KIDNEY	PLOD3 →	+1.384	+0.191	<.001	<.001	3	4
BREAST	SUOX →	-0.998	-0.182	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KRT18 by Gastrulation activity — LUNG_SCLC

Explore this box plot interactively →