Thorax and anterior abdomen determination

Across TCGA patient cohorts, RNA activity of the Thorax and anterior abdomen determination pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BASP1, GALM, and RPS6KA3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thorax and anterior abdomen determination activity versus BASP1 in GBM (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BASP1 →	+0.765	+0.186	<.001	<.001	3	8
UCEC	GALM →	-0.415	-0.136	.004	.004	3	8
BRCA	RPS6KA3 →	-0.313	-0.090	.002	.005	3	6
HNSC	TESPA1_S311 →	-0.905	-0.151	<.001	.007	3	6
UCEC	BASP1_T36 →	+0.776	+0.177	<.001	.002	3	6
BRCA	CD3E →	-0.437	-0.108	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007356 vs BASP1 — GBM

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