"Zygotic determination of anterior/posterior axis, embryo"

Across TCGA patient cohorts, RNA activity of the "Zygotic determination of anterior/posterior axis, embryo" pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BASP1, ABCA6, and MMP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Zygotic determination of anterior/posterior axis, embryo" activity versus BASP1 in HNSC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BASP1 →	+1.496	+0.606	<.001	.003	2	7
OV	ABCA6 →	+0.644	+0.616	.005	.004	3	4
HNSC	MMP2 →	+1.033	+0.633	<.001	.001	3	4
HNSC	DCN →	+0.703	+0.409	.008	.006	3	4
PDAC	ARL4AP1 →	-0.389	-0.109	.005	<.001	3	3
HNSC	LSM1P1 →	+1.298	+0.749	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007354 vs BASP1 — HNSC

Explore this scatter interactively →