Tripartite regional subdivision

Across TCGA cell cohorts, RNA activity of the Tripartite regional subdivision pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCALD, UTS2B, and B3GALNT2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NCALD grouped by Tripartite regional subdivision-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NCALD →	+0.215	+1.917	<.001	<.001	3	3
STOMACH	UTS2B →	+0.159	+1.768	.008	<.001	3	3
LUNG_SCLC	B3GALNT2 →	+0.261	+1.309	.003	.005	3	3
SKIN	MDH2 →	-0.208	-0.952	<.001	.003	3	3
BLOOD_Myeloma	PRPS1L1 →	-0.229	-1.928	.005	<.001	3	3
LIVER	ASB18 →	+0.173	+2.119	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NCALD by Tripartite regional subdivision activity — LIVER

Explore this box plot interactively →