Tripartite regional subdivision

Across TCGA pan-cancer cohorts, RNA activity of the Tripartite regional subdivision pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 20 member genes.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher Tripartite regional subdivision pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as THCA and READ, show the opposite pattern, with higher activity associated with better survival.

PAAD, HNSC, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Tertile	All	0.341	0.674	.001	43	view →
HNSC	OS	Quartile	III,IV	0.529	0.710	.006	40	view →
UCEC	OS	Median	All	0.578	0.765	<.001	36	view →
KICH	DFS	Quartile	II,III,IV	0.500	1.000	.002	34	view →
THCA	OS	Median	All	0.982	0.897	.003	33	view →
ACC	OS	Tertile	All	0.292	0.790	.001	31	view →
LUAD	DFS	Median	II,III,IV	0.315	0.552	.008	30	view →
COAD	DFS	Quartile	III,IV	0.542	0.722	.014	23	view →
CESC	DFS	Tertile	II,III,IV	0.551	0.799	.006	22	view →
KIRC	OS	Quartile	All	0.501	0.719	.009	21	view →
KIRP	OS	Median	II,III,IV	0.720	0.919	.008	20	view →
SARC	OS	Median	All	0.665	0.843	.003	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0007351–PAAD (OS)

Open the PAAD breakdown →