Tripartite regional subdivision

Across TCGA cell cohorts, RNA activity of the Tripartite regional subdivision pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BASP1, SYNPO, and SERPINB2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tripartite regional subdivision activity versus BASP1 in LUNG_SCLC (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BASP1 →	+4.850	+1.352	<.001	<.001	2	8
SKIN	SYNPO →	+1.767	+1.203	<.001	.001	3	6
SKIN	SERPINB2 →	+2.913	+0.975	.006	.009	2	6
LIVER	TGFB2 →	+3.489	+1.805	.001	<.001	3	5
LIVER	RPS6KA4 →	+1.272	+1.828	.004	<.001	3	5
LIVER	ADTRP →	+1.486	+1.447	.007	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007351 vs BASP1 — LUNG_SCLC

Explore this scatter interactively →