Blastoderm segmentation

Across TCGA patient cohorts, RNA activity of the Blastoderm segmentation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC43A2, ECM1, and IGFBP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Blastoderm segmentation activity versus SLC43A2 in COAD (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SLC43A2 →	-0.250	-0.025	.006	.002	3	5
BRCA	ECM1 →	+0.609	+0.038	<.001	<.001	3	5
GBM	IGFBP3 →	+0.786	+0.073	.001	<.001	3	5
LSCC	SEC11C →	-0.966	-0.055	<.001	<.001	3	5
LSCC	VAV1 →	-0.397	-0.061	.001	.001	3	5
LSCC	BTK →	-0.341	-0.045	.003	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007350 vs SLC43A2 — COAD

Explore this scatter interactively →