Blastoderm segmentation

Across TCGA pan-cancer cohorts, RNA activity of the Blastoderm segmentation pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 25 member genes.

The strongest signal is observed in thyroid carcinoma (THCA), where higher Blastoderm segmentation pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as THCA and BRCA, show the opposite pattern, with higher activity associated with better survival.

THCA, LUAD, and CESC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Quartile	All	1.000	0.878	.001	59	view →
LUAD	DFS	Quartile	All	0.556	0.722	.002	57	view →
CESC	DFS	Quartile	All	0.571	0.809	.001	52	view →
KIRC	OS	Quartile	All	0.516	0.685	.002	36	view →
LGG	DFS	Tertile	All	0.750	0.866	.001	35	view →
HNSC	OS	Tertile	III,IV	0.207	0.420	.011	33	view →
PAAD	OS	Quartile	All	0.318	0.683	<.001	30	view →
KIRP	DFS	Quartile	III,IV	0.286	0.790	.002	27	view →
SARC	OS	Quartile	All	0.677	0.865	.001	19	view →
CHOL	OS	Tertile	II,III,IV	0.318	0.934	.010	19	view →
UCEC	DFS	Median	All	0.864	0.922	.009	18	view →
KICH	DFS	Median	II,III,IV	0.549	0.919	.003	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0007350–THCA (OS)

Open the THCA breakdown →