Blastoderm segmentation

Across TCGA patient cohorts, RNA activity of the Blastoderm segmentation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMTM2, NINJ1, and TBX3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Blastoderm segmentation activity versus CMTM2 in HNSC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CMTM2 →	+0.433	+0.520	.001	.001	3	4
BRCA	NINJ1 →	+0.728	+0.335	.001	.006	3	3
BRCA	TBX3 →	+1.346	+0.586	<.001	<.001	3	3
BRCA	IGFBP4 →	+0.681	+0.379	.001	<.001	3	3
BRCA	EIF4EBP3 →	+0.434	+0.314	.002	.005	3	3
BRCA	SNAI3-AS1 →	+0.340	+0.485	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007350 vs CMTM2 — HNSC

Explore this scatter interactively →