Blastoderm segmentation

Across TCGA cell cohorts, RNA activity of the Blastoderm segmentation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BASP1, CD109, and IKBKG, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Blastoderm segmentation activity versus BASP1 in LUNG_NSCLC_LUAD (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BASP1 →	+4.337	+1.119	<.001	<.001	3	10
LIVER	CD109 →	+2.614	+1.608	.003	<.001	3	5
LIVER	IKBKG →	+1.729	+1.447	.006	.005	3	5
LUNG_SCLC	PFKP →	+1.494	+1.275	<.001	<.001	3	4
OVARY	TGFB2 →	+2.198	+1.054	.007	.002	3	4
SOFT_TISSUE	CEBPA →	-1.400	-1.265	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007350 vs BASP1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →