Acrosome reaction

Across TCGA patient cohorts, RNA activity of the Acrosome reaction pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAT5A, APOBEC3C, and IL16, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acrosome reaction activity versus STAT5A in GBM (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STAT5A →	-0.288	-0.029	.003	.004	3	5
BRCA	APOBEC3C →	-0.532	-0.030	.001	.008	3	5
BRCA	IL16 →	-0.449	-0.031	<.001	<.001	3	5
LSCC	LAP3_S238 →	-0.520	-0.042	<.001	.001	3	5
LSCC	RASAL3_S819 →	-0.663	-0.040	<.001	<.001	3	5
COAD	ADA →	-0.417	-0.018	.003	.009	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007340 vs STAT5A — GBM

Explore this scatter interactively →