Insemination

Across TCGA cell cohorts, RNA activity of the Insemination pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINA5, KLK14, and SERPINA3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Insemination activity versus SERPINA5 in LIVER (Pearson r = 0.92).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SERPINA5 →	+4.389	+2.263	<.001	<.001	3	7
LUNG_SCLC	KLK14 →	+1.415	+0.527	<.001	.007	3	7
SKIN	SERPINA3 →	+3.804	+1.136	<.001	<.001	3	5
BLOOD_Leukemia	FAM53A →	-0.465	-0.131	.004	<.001	3	5
LIVER	AZGP1 →	+2.098	+1.337	.005	.008	2	5
LIVER	RPE →	-0.641	-1.716	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007320 vs SERPINA5 — LIVER

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