Female gamete generation

Across TCGA patient cohorts, RNA activity of the Female gamete generation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ESPL1, DIAPH3, and ESCO2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Female gamete generation activity versus ESPL1 in LSCC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ESPL1 →	+0.714	+0.248	.003	.007	3	5
LSCC	DIAPH3 →	+0.772	+0.302	.002	.008	3	5
LSCC	ESCO2 →	+0.742	+0.315	<.001	.007	3	5
BRCA	KIF14 →	+0.794	+0.231	<.001	.002	3	5
PDAC	ATAD5 →	+0.526	+0.586	<.001	.007	3	5
BRCA	TOP2A →	+1.072	+0.272	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007292 vs ESPL1 — LSCC

Explore this scatter interactively →