Neuron-neuron synaptic transmission

Across TCGA patient cohorts, RNA activity of the Neuron-neuron synaptic transmission pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU7-41P, CKS1BP3, and CENPL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron-neuron synaptic transmission activity versus RNU7-41P in HNSC (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU7-41P →	-0.842	-0.127	<.001	.004	3	3
HNSC	CKS1BP3 →	-0.601	-0.138	.002	.001	3	3
CCRCC	CENPL →	-0.327	-0.112	.005	.007	3	3
CCRCC	COLGALT1 →	-0.356	-0.130	.007	.003	3	3
CCRCC	SHCBP1 →	-0.509	-0.124	.002	.001	3	3
CCRCC	PTPN2 →	-0.421	-0.156	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007270 vs RNU7-41P — HNSC

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