Neurotransmitter secretion

Across TCGA cell cohorts, RNA activity of the Neurotransmitter secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AQP4, MLC1, and FUT1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AQP4 grouped by Neurotransmitter secretion-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	AQP4 →	-0.229	-1.370	.001	<.001	3	7
BLOOD_Myeloma	MLC1 →	-0.637	-1.519	.002	<.001	3	7
BLOOD_Myeloma	FUT1 →	-0.566	-1.616	<.001	<.001	3	6
LARGE_INTESTINE	NECTIN2 →	-0.295	-0.962	<.001	.003	3	6
STOMACH	BMX →	-0.235	-1.385	.005	.001	2	7
LIVER	VTCN1 →	-0.255	-1.328	.006	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AQP4 by Neurotransmitter secretion activity — URINARY_TRACT

Explore this box plot interactively →