Nitric oxide mediated signal transduction

Across TCGA patient cohorts, RNA activity of the Nitric oxide mediated signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GUCY1A1, PECAM1, and GUCY1B1, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nitric oxide mediated signal transduction activity versus GUCY1A1 in UCS (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	GUCY1A1 →	+1.647	+0.067	<.001	<.001	3	30
ESCA	PECAM1 →	+1.470	+0.088	<.001	<.001	3	30
LAML	GUCY1B1 →	+1.421	+0.068	<.001	<.001	3	30
ACC	F13A1 →	+1.833	+0.033	<.001	<.001	3	30
ACC	CD93 →	+1.577	+0.065	<.001	<.001	3	30
READ	CSF2RB →	+1.237	+0.044	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007263 vs GUCY1A1 — UCS

Explore this scatter interactively →