Nitric oxide mediated signal transduction

Across TCGA pan-cancer cohorts, RNA activity of the Nitric oxide mediated signal transduction pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 29 member genes.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher Nitric oxide mediated signal transduction pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SARC, show the opposite pattern, with higher activity associated with better survival.

LUSC, MESO, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.306	0.445	.006	26	view →
MESO	OS	Median	II,III,IV	0.362	0.683	.018	21	view →
HNSC	DFS	Quartile	IV	0.701	0.486	.005	17	view →
STAD	DFS	Quartile	All	0.394	0.531	.021	15	view →
SARC	OS	Quartile	All	0.934	0.710	.004	15	view →
THCA	DFS	Median	IV	0.975	0.770	.009	15	view →
BLCA	DFS	Quartile	IV	0.184	0.341	.029	13	view →
SKCM	DFS	Tertile	All	0.663	0.540	.014	13	view →
SCLC	OS	Median	II,III,IV	1.000	0.501	.012	13	view →
ESCA	OS	Median	All	0.617	1.000	.009	12	view →
LUAD	DFS	Median	IV	0.535	0.854	.008	12	view →
BRCA	DFS	Tertile	IV	0.274	0.681	.022	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0007263–LUSC (DFS)

Open the LUSC breakdown →