Nitric oxide mediated signal transduction

Across TCGA patient cohorts, RNA activity of the Nitric oxide mediated signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BGN, NOL11, and RCL1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nitric oxide mediated signal transduction activity versus BGN in UCEC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BGN →	+0.869	+0.110	<.001	<.001	3	10
LSCC	NOL11 →	-0.307	-0.071	<.001	<.001	3	9
PDAC	RCL1 →	-0.323	-0.085	<.001	.002	3	9
LSCC	MPHOSPH10 →	-0.384	-0.083	<.001	<.001	3	9
CCRCC	TNS2_S120 →	+0.558	+0.102	<.001	<.001	3	9
CCRCC	CD34 →	+0.639	+0.098	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007263 vs BGN — UCEC

Explore this scatter interactively →