Nitric oxide mediated signal transduction

Across TCGA cell cohorts, RNA activity of the Nitric oxide mediated signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL5, RELB, and IL6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLHL5 grouped by Nitric oxide mediated signal transduction-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	KLHL5 →	-1.378	-1.389	<.001	<.001	3	5
LUNG_NSCLC_LUAD	RELB →	-0.982	-0.690	.001	.002	3	4
LUNG_NSCLC_LUAD	IL6 →	-2.688	-1.004	.001	.001	3	4
STOMACH	RPL34 →	+0.591	+1.116	.003	<.001	3	4
LUNG_SCLC	MYL9 →	-4.133	-1.258	.001	.001	3	4
LUNG_SCLC	SNX8 →	-1.404	-1.176	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLHL5 by Nitric oxide mediated signal transduction activity — LIVER

Explore this box plot interactively →