Nitric oxide mediated signal transduction

Across TCGA cell cohorts, RNA activity of the Nitric oxide mediated signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BICRAL, ATP2B4, and APOE, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nitric oxide mediated signal transduction activity versus BICRAL in BLOOD_Lymphoma (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BICRAL →	-0.876	-0.757	.003	.005	3	7
BLOOD_Lymphoma	ATP2B4 →	+3.807	+1.293	<.001	<.001	3	7
SOFT_TISSUE	APOE →	+2.372	+0.128	.001	<.001	3	6
BREAST	THBS1 →	+2.896	+0.129	.001	.007	3	6
BLOOD_Leukemia	DNAJC6 →	+1.687	+0.143	.002	.002	3	6
BONE	DDAH1 →	+2.968	+0.284	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007263 vs BICRAL — BLOOD_Lymphoma

Explore this scatter interactively →