Nitric oxide mediated signal transduction

Across TCGA cell cohorts, RNA activity of the Nitric oxide mediated signal transduction pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-A, STRADB, and SELP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HLA-A grouped by Nitric oxide mediated signal transduction-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	HLA-A →	+0.160	+0.488	.004	.006	2	4
LARGE_INTESTINE	STRADB →	+0.190	+1.039	.003	.003	3	3
BLOOD_Leukemia	SELP →	-0.360	-1.639	.006	.001	3	3
SOFT_TISSUE	DDIT3 →	-0.178	-1.827	.009	.002	2	4
SOFT_TISSUE	KRT18P55 →	+0.330	+2.002	<.001	<.001	3	3
SKIN	KLK14 →	-0.232	-1.069	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HLA-A by Nitric oxide mediated signal transduction activity — BLOOD_Myeloma

Explore this box plot interactively →