Tyrosine phosphorylation of STAT protein

Across TCGA cell cohorts, RNA activity of the Tyrosine phosphorylation of STAT protein pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR2H, GGACT, and EIF2B2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLR2H grouped by Tyrosine phosphorylation of STAT protein-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	POLR2H →	+0.485	+0.931	<.001	<.001	3	5
SKIN	GGACT →	-0.828	-0.889	.003	.003	3	4
BLOOD_Lymphoma	EIF2B2 →	+1.347	+1.500	.004	.006	3	4
LARGE_INTESTINE	MRM3 →	+0.688	+0.998	.005	.001	3	4
BLOOD_Myeloma	ATP5F1B →	+1.131	+1.412	.005	.001	2	5
LUNG_NSCLC_LUAD	RAB4A →	-0.426	-0.711	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLR2H by Tyrosine phosphorylation of STAT protein activity — SKIN

Explore this box plot interactively →