Osmosensory signaling pathway

Across TCGA patient cohorts, RNA activity of the Osmosensory signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD69, FRMD3, and RPL37AP8, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Osmosensory signaling pathway activity versus CD69 in OV (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CD69 →	+0.957	+0.151	.001	.009	3	3
PDAC	FRMD3 →	-0.418	-0.104	.004	.004	3	3
PDAC	RPL37AP8 →	-0.353	-0.074	.002	.004	3	3
GBM	UNC45B →	-0.045	-0.240	.002	.003	3	3
GBM	HMGA1P4 →	-0.516	-0.330	.001	.001	3	3
COAD	C1DP5 →	-0.350	-0.104	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007231 vs CD69 — OV

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