Osmosensory signaling pathway

Across TCGA cell cohorts, RNA activity of the Osmosensory signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ODC1, NKX2-8, and PHGDH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ODC1 grouped by Osmosensory signaling pathway-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ODC1 →	+0.911	+1.039	<.001	.004	3	3
LUNG_NSCLC_LUAD	NKX2-8 →	+0.752	+0.496	.002	.008	2	4
OVARY	PHGDH →	+1.927	+1.005	.001	.004	3	3
SOFT_TISSUE	TRIM6 →	-1.658	-0.790	.001	.004	3	3
SOFT_TISSUE	ZFP92 →	-0.406	-1.029	.007	.002	3	3
BLOOD_Leukemia	SLC22A15 →	+2.512	+0.855	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ODC1 by Osmosensory signaling pathway activity — LARGE_INTESTINE

Explore this box plot interactively →