Osmosensory signaling pathway

Across TCGA cell cohorts, RNA activity of the Osmosensory signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP89, CCDC12, and VIPR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Osmosensory signaling pathway activity versus CEP89 in LIVER (Pearson r = -0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CEP89 →	-1.085	-0.168	.003	<.001	3	5
CNS	CCDC12 →	+1.095	+0.352	<.001	<.001	3	5
LARGE_INTESTINE	VIPR1 →	+1.601	+0.214	.004	.003	3	4
LIVER	KDELR1 →	-0.769	-0.168	.008	<.001	3	4
LIVER	WDR36 →	+0.582	+0.168	.007	<.001	3	4
LIVER	C18orf21 →	-0.430	-0.170	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007231 vs CEP89 — LIVER

Explore this scatter interactively →