Integrin-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Integrin-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UFC1, PPP1R12A, and MAX, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UFC1 grouped by Integrin-mediated signaling pathway-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	UFC1 →	+0.231	+0.131	<.001	.004	3	6
BREAST	PPP1R12A →	+0.263	+0.180	.007	.001	2	7
BONE	MAX →	-0.597	-0.371	.003	.005	3	6
SKIN	KDELR1 →	-0.208	-0.152	<.001	.002	3	6
KIDNEY	ZCCHC3 →	+0.254	+0.117	.006	.001	3	6
LARGE_INTESTINE	LMTK2 →	-0.261	-0.108	.008	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UFC1 by Integrin-mediated signaling pathway activity — CNS

Explore this box plot interactively →