Smoothened signaling pathway

Across TCGA patient cohorts, RNA activity of the Smoothened signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYH10, CLEC11A, and TAGLN, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Smoothened signaling pathway activity versus MYH10 in COAD (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MYH10 →	+0.571	+0.027	<.001	<.001	3	9
BRCA	CLEC11A →	+0.583	+0.024	<.001	<.001	3	9
BRCA	TAGLN →	+0.687	+0.026	<.001	<.001	3	9
BRCA	TIMP2 →	+0.671	+0.028	<.001	<.001	3	8
BRCA	TLN2 →	+0.628	+0.032	<.001	<.001	3	8
HNSC	VCAN →	+1.018	+0.050	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007224 vs MYH10 — COAD

Explore this scatter interactively →