Smoothened signaling pathway

Across TCGA patient cohorts, RNA activity of the Smoothened signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P3H3, P3H4, and POFUT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Smoothened signaling pathway activity versus P3H3 in LSCC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	P3H3 →	+0.646	+0.307	.001	<.001	3	5
LSCC	P3H4 →	+0.588	+0.327	<.001	<.001	3	5
LSCC	POFUT2 →	+0.316	+0.249	.003	.009	3	4
BRCA	SYS1-DBNDD2 →	+0.331	+0.752	<.001	<.001	3	4
CCRCC	CCDC113 →	+0.905	+0.506	<.001	.001	3	3
BRCA	TCTN3 →	+0.412	+0.670	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007224 vs P3H3 — LSCC

Explore this scatter interactively →