Smoothened signaling pathway

Across TCGA patient cohorts, RNA activity of the Smoothened signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TCTN1, DVL1_S604, and IFT172, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Smoothened signaling pathway activity versus TCTN1 in LSCC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TCTN1 →	+0.495	+0.267	<.001	.001	3	3
GBM	DVL1_S604 →	+0.844	+1.813	<.001	<.001	3	3
BRCA	IFT172 →	+0.286	+0.750	<.001	<.001	3	3
OV	KATNIP_S660 →	+0.615	+0.631	.002	.001	3	3
LUAD	SRSF11_S449 →	-1.718	-0.228	<.001	.001	3	2
BRCA	DOT1L_S1104 →	-0.431	-0.622	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007224 vs TCTN1 — LSCC

Explore this scatter interactively →