Smoothened signaling pathway

Across TCGA cell cohorts, RNA activity of the Smoothened signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GET1-SH3BGR, B3GNT4, and MEIOB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GET1-SH3BGR grouped by Smoothened signaling pathway-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GET1-SH3BGR →	-0.266	-0.185	.006	.002	3	3
LUNG_NSCLC_LUSC	B3GNT4 →	+0.110	+1.367	<.001	.002	2	4
LUNG_NSCLC_LUAD	MEIOB →	-0.189	-0.813	.001	<.001	3	3
LUNG_NSCLC_LUAD	POU3F2 →	-0.237	-1.165	<.001	<.001	3	3
BREAST	TTC19 →	-0.168	-1.257	.006	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	ERICH6B →	-0.233	-1.597	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GET1-SH3BGR by Smoothened signaling pathway activity — SKIN

Explore this box plot interactively →