Positive regulation of transcription of Notch receptor target

Across TCGA patient cohorts, RNA activity of the Positive regulation of transcription of Notch receptor target pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LDHD, NPM1P46, and GJB6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transcription of Notch receptor target activity versus LDHD in BRCA (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LDHD →	-0.727	-0.481	.008	.008	3	4
LUAD	NPM1P46 →	+0.150	+0.137	.008	.008	3	4
PDAC	GJB6 →	-0.706	-0.198	.007	.004	3	3
PDAC	RPL22P11 →	+0.509	+0.307	<.001	.001	3	3
COAD	STMN2 →	-1.314	-0.542	<.001	<.001	3	3
LUAD	RAPGEF6 →	+0.293	+0.184	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007221 vs LDHD — BRCA

Explore this scatter interactively →