Notch receptor processing

Across TCGA patient cohorts, RNA activity of the Notch receptor processing pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_S368, MAN2C1, and SMC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Notch receptor processing activity versus RFC1_S368 in GBM (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RFC1_S368 →	-0.710	-0.069	<.001	<.001	3	6
BRCA	MAN2C1 →	+0.328	+0.049	<.001	<.001	3	6
GBM	SMC2 →	-0.596	-0.072	<.001	<.001	3	6
GBM	SMC4 →	-0.594	-0.063	<.001	<.001	3	6
OV	PCF11_S511 →	-0.615	-0.071	.005	.006	3	6
BRCA	DDAH2 →	+0.259	+0.038	.009	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007220 vs RFC1_S368 — GBM

Explore this scatter interactively →