Neuropeptide signaling pathway

Across TCGA patient cohorts, RNA activity of the Neuropeptide signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2T, TEDC2, and RNU7-75P, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuropeptide signaling pathway activity versus UBE2T in LSCC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UBE2T →	-0.627	-0.372	<.001	<.001	3	6
CCRCC	TEDC2 →	-0.386	-0.742	<.001	<.001	3	6
PDAC	RNU7-75P →	-0.381	-0.438	.009	.009	3	5
UCEC	NUDT1 →	-0.805	-0.377	.001	.003	3	5
UCEC	EFTUD2 →	-0.491	-0.327	.001	.002	3	5
UCEC	CCT5 →	-0.766	-0.342	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007218 vs UBE2T — LSCC

Explore this scatter interactively →