Tachykinin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Tachykinin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF654, HEBP1, and ATF4P1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tachykinin receptor signaling pathway activity versus ZNF654 in UCEC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF654 →	-0.530	-0.699	.001	.001	3	4
COAD	HEBP1 →	-0.575	-0.860	<.001	<.001	3	4
OV	ATF4P1 →	+0.260	+0.759	.001	<.001	3	3
HNSC	CSRNP2 →	-0.422	-0.152	<.001	<.001	3	3
COAD	LOXL1 →	-0.950	-0.754	<.001	.001	3	3
HNSC	ST6GAL2 →	-0.894	-0.125	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007217 vs ZNF654 — UCEC

Explore this scatter interactively →