Tachykinin receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Tachykinin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP55, STAC, and MTMR14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CEP55 grouped by Tachykinin receptor signaling pathway-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CEP55 →	-0.761	-1.320	.009	.003	3	4
SOFT_TISSUE	STAC →	-2.811	-1.337	.004	.002	3	4
SOFT_TISSUE	MTMR14 →	-0.808	-1.359	.003	.005	3	4
SOFT_TISSUE	BDNF →	-1.880	-1.012	.006	.003	3	4
URINARY_TRACT	MARVELD2 →	+3.093	+1.784	.002	<.001	3	4
SKIN	TLR4 →	-1.205	-0.976	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CEP55 by Tachykinin receptor signaling pathway activity — SOFT_TISSUE

Explore this box plot interactively →