G protein-coupled glutamate receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the G protein-coupled glutamate receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLAC9, EIF5B_S1168, and RFTN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, G protein-coupled glutamate receptor signaling pathway activity versus PLAC9 in PDAC (Pearson r = -0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PLAC9 →	-0.793	-0.068	<.001	<.001	3	6
LUAD	EIF5B_S1168 →	+0.414	+0.071	<.001	<.001	3	5
BRCA	RFTN1 →	-0.361	-0.063	.002	.006	3	5
BRCA	KLC2_S151 →	+0.655	+0.071	.001	.002	3	5
LSCC	SORBS3 →	-0.218	-0.164	.001	.009	3	5
LSCC	TNS2 →	-0.210	-0.207	.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007216 vs PLAC9 — PDAC

Explore this scatter interactively →